Arizona Cardinals vs Seattle Seahawks Point Spread Picks

Seattle is switching quarterbacks today, with Sam Darnold out and Drew Lock starting, and that's the fact that matters most here. But the Seahawks won last week by playing exactly how a Lock-led offense is supposed to play again: conservative, mistake-free, and leaning on a defense that held New England to 13 points despite the Patriots controlling the ball for over 34 minutes. Arizona was efficient in its own opener, controlling the ball for nearly 38 minutes in a win over the Chargers, but that came against a Los Angeles defense, not Seattle's. The Seahawks didn't turn the ball over once last week either, and a low-mistake, ball-control approach from both sides tends to keep games within a score, which is what this number is asking for. Arizona's offensive line and ground game are the strength of that team, and Seattle's defense will have to answer, but I trust that defense, which just held a desperate Patriots team to 13, not to hand Arizona the extra possessions it will need to pull away. Side with Seattle on the spread today.

Arizona comes off a huge confidence-builder, defeating the Cowboys 27-17 on Monday night after losing five close games in a row. The Cardinals are much better than their record indicates, and Jacoby Brissett will get the start again after throwing for 261 yards and two TDs with no interceptions. Emari Demercardo rushed for 79 yards on 5.6 per carry. The defense also came up big with some clutch plays in the second half. The Cardinals have covered their last five road games, and they are 8-0 ATS on the road against teams with winning home records dating back to last season. Seattle is 2-9-2 ATS after allowing fewer than 150 yards passing in their previous game. The Seahawks are 2-8 ATS their past 10 after a win by more than 14 points, and they are 5-1 OVER following a win. Also, Seattle has gone OVER four of five home games and five of seven overall. Arizona is in a revenge spot after losing the first meeting 23-20. Take the Cardinals and the OVER.

Seattle has beaten the Cardinals seven times in a row and three of the past four meetings have gone UNDER. The Seahawks are allowing only 15.7 points per game this season, which is #2 in the league. Arizona allows 17.0 and its 16-15 last-second loss to San Francisco went UNDER by 13.5 points. Sam Darnold is proving that his career year with the Vikings in 2024 wasn't a fluke as he continues to impress with the Seahawks. He has thrown for 663 yards and four TDs this season. Darnold was 14 of 18 for 218 yards with no interceptions against New Orleans on Sunday. He has completed 70.3 percent of his passes and has been sacked just three times. Seattle has gone UNDER nine of 13 against the NFC West. The Cardinals totaled only 260 yards and Kyler Murray was 22 of 35 for 159 yards and no TDs against the 49ers. Arizona has gone UNDER five of six against teams with winning records dating to last season. Take the Seahawks/Cardinals to play UNDER the total.

Arizona blew a 13-point lead and lost 23-22 at Minnesota on Sunday, but the Cardinals got the money to improve to 8-4 ATS. Seattle is just 4-5 ATS its past nine games, and the Cardinals are seeking to avenge a 16-6 loss to the Seahawks on Nov. 24. Kyler Murray threw for 260 yards but was picked off twice against the Vikings, who were outgained 406-273 by Arizona. The Cardinals are 4-0 ATS after totaling more than 350 yards in their previous game. Seattle came from behind to beat the New York Jets 26-21, and it went OVER by five points. Geno Smith threw for 206 yards, and the Seahawks shut out the Jets in the second half. The Cardinals had won four in a row before losing to the Seahawks and the Vikings, and they are looking for Arizona and Murray to bounce back from last week's loss at home in this critical NFC West battle. Take the Cardinals and the OVER.

Arizona is 7-3 ATS this season and has won and covered four in a row following a 31-6 rout of the New York Jets two weeks before the bye week. The Cardinals have allowed only 14.3 points per game during the streak, and three of them went UNDER. Kyler Murray played a near-perfect game against the Jets, finishing 22 of 24 for 266 yards and scoring a touchdown with no picks. New York was held to just 207 total yards of offense, and the game stayed UNDER by nine points. Seattle used to be one of the most challenging places for opponents to play, but the Seahawks are just 1-6 ATS in their past seven home games and 2-4 straight up this season. Seattle is 4-9 ATS in its past 13 games versus the NFC West teams, although it pulled out a 20-17 victory over San Francisco last week. Geno Smith scored on a 13-yard run with 12 seconds left to win it for the Seahawks, who have scored only 16.7 points per game in their past three games. Take the Cardinals and the UNDER.