Even if Brock Purdy returns for the 49ers this week, San Francisco is too depleted defensively to be laying points on the road against a division rival, especially one as desperate as the 3-6 Cardinals. This is the Cardinals' season. They will be going all out after their embarrassing, 44-22, road loss to the Seahawks last week. Up until that game, Arizona had not lost by more than four points all season. Their previous five losses came by a combined 13 points. One of these was a 16-15 road loss to the 49ers on Sept. 21. San Francisco edged the Cardinals by making a 35-yard field goal on the final play. Jacoby Brissett has replaced injured Kyler Murray since that game, and Arizona's offense has responded better. Injuries to multiple players, including their two best defenders - pass rusher Nick Bosa and linebacker Fred Warner - have taken a toll on the 49ers as they have allowed an average of 30.6 points per game in their last three games. Both offenses are going to be conservative to protect their defenses. Take the Cardinals on the moneyline and the UNDER.
Previous Matchups & Picks
Lines & Odds
49ers vs. Cardinals Spread Picks
Get this week's 49ers vs. Cardinals point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between 49ers vs. Cardinals.
Public Consensus
Who was the public on? 65% of the public bets were on San Francisco 49ers on the -3.5 ATS. And, 57% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that Arizona would win by a score of 24.0 to 23.5 with Arizona winning on the moneyline and on the spread and the game going UNDER the total.
Pro Picks
NFL
San Francisco at Arizona
4:05 PM Eastern
Final Score
NFL Pro Pick Results
Here’s how my Pro Picks are performing.
Lines & Odds
Public Consensus
Who was the public on? 52% of the public bets were on San Francisco 49ers on the -1.5 ATS. And, 51% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 23.2 to 22.0 with San Francisco winning on the moneyline, Arizona winning on the spread and the game going OVER the total.
Final Score
Lines & Odds
Public Consensus
Who was the public on? 60% of the public bets were on Arizona Cardinals on the -4.5 ATS. And, 59% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Arizona would win by a score of 23.3 to 20.7 with Arizona winning on the moneyline, San Francisco winning on the spread and the game going OVER the total.
Final Score
Lines & Odds
Public Consensus
Who was the public on? 55% of the public bets were on Arizona Cardinals on the +7 ATS. And, 58% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 27.3 to 20.0 with San Francisco winning on the moneyline and on the spread and the game going UNDER the total.
Pro Picks
PARLAY
San Francisco (NFL-468) MONEYLINE + Seattle (NFL-472) MONEYLINE
4:05 PM Eastern
Combine the 49ers (-355) and the Seahawks (-310) into a 2-team parlay at -144 odds.
Final Score
Lines & Odds
Public Consensus
Who was the public on? 55% of the public bets were on San Francisco 49ers on the -12 ATS. And, 62% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 30.8 to 17.2 with San Francisco winning on the moneyline and on the spread.
Pro Picks
NFL
San Francisco at Arizona
4:05 PM Eastern
Arizona has split four games since Kyler Murray's return, including a 24-10 victory at Pittsburgh two weeks ago before the bye. San Francicso won the first meeting 35-16 on Oct. 1 when Murray was still out. Murray has thrown for 864 yards on a 60.8 percent completion rate with three TDs and two interceptions since returning to the lineup. James Connor has 631 rushing yards on 4.9 yards per carry. The 49ers are just 3-4 ATS their past seven games and didn't cover while defeating Seattle 28-16 as a 16.5-point favorite and the game stayed UNDER. Arizona went UNDER by three points against the Steelers and the Cardinals are 5-3 UNDER their past eight games. Arizona has covered four straight against teams with winning road records and it is 7-2-1 ATS its past 10 games after allowing fewer than 15 points its previous game. The Cardinals are 6-2 UNDER following a bye week and they have gone UNDER five of their past six December games. Take the Cardinals and the UNDER.
Final Score
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