Even if Brock Purdy returns for the 49ers this week, San Francisco is too depleted defensively to be laying points on the road against a division rival, especially one as desperate as the 3-6 Cardinals. This is the Cardinals' season. They will be going all out after their embarrassing, 44-22, road loss to the Seahawks last week. Up until that game, Arizona had not lost by more than four points all season. Their previous five losses came by a combined 13 points. One of these was a 16-15 road loss to the 49ers on Sept. 21. San Francisco edged the Cardinals by making a 35-yard field goal on the final play. Jacoby Brissett has replaced injured Kyler Murray since that game, and Arizona's offense has responded better. Injuries to multiple players, including their two best defenders - pass rusher Nick Bosa and linebacker Fred Warner - have taken a toll on the 49ers as they have allowed an average of 30.6 points per game in their last three games. Both offenses are going to be conservative to protect their defenses. Take the Cardinals on the moneyline and the UNDER.
Previous Matchups & Picks
Lines & Odds
Cardinals vs. 49ers Spread Picks
Get this week's Cardinals vs. 49ers point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Cardinals vs. 49ers.
Public Consensus
Who was the public on? 84% of the public bets were on San Francisco 49ers on the -7.5 ATS. 98% of the public money was on San Francisco 49ers to win on the moneyline. And, 60% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 30.4 to 17.7 with San Francisco winning on the moneyline and on the spread and the game going UNDER the total.
Final Score
NFL Pro Pick Results
Here’s how my Pro Picks are performing.
Lines & Odds
Public Consensus
Who was the public on? 65% of the public bets were on San Francisco 49ers on the -3.5 ATS. And, 57% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that Arizona would win by a score of 24.0 to 23.5 with Arizona winning on the moneyline and on the spread and the game going UNDER the total.
Pro Picks
NFL
San Francisco at Arizona
4:05 PM Eastern
Final Score
Lines & Odds
Public Consensus
Who was the public on? 52% of the public bets were on San Francisco 49ers on the -1.5 ATS. And, 51% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 23.2 to 22.0 with San Francisco winning on the moneyline, Arizona winning on the spread and the game going OVER the total.
Final Score
Lines & Odds
Public Consensus
Who was the public on? 60% of the public bets were on Arizona Cardinals on the -4.5 ATS. And, 59% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Arizona would win by a score of 23.3 to 20.7 with Arizona winning on the moneyline, San Francisco winning on the spread and the game going OVER the total.
Final Score
Lines & Odds
Public Consensus
Who was the public on? 55% of the public bets were on Arizona Cardinals on the +7 ATS. And, 58% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that San Francisco would win by a score of 27.3 to 20.0 with San Francisco winning on the moneyline and on the spread and the game going UNDER the total.
Pro Picks
PARLAY
San Francisco (NFL-468) MONEYLINE + Seattle (NFL-472) MONEYLINE
4:05 PM Eastern
Combine the 49ers (-355) and the Seahawks (-310) into a 2-team parlay at -144 odds.
Final Score
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