Previous Matchups & Picks

November 23, 2025 4:05pm ET
@
Jacksonville Jaguars
Jacksonville Jaguars
#255
Arizona Cardinals
Arizona Cardinals
#256

Lines & Odds

-2.5 (-105)
ATS
+2.5 (-115)
-133
Moneyline
+113
OVER 47 (-110)
Total
UNDER 47 (-110)

Jaguars vs. Cardinals Spread Picks

Get this week's Jaguars vs. Cardinals point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Jaguars vs. Cardinals.

Public Consensus

Who was the public on? 55% of the public bets were on Jacksonville Jaguars on the -2.5 ATS. And, 58% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Arizona would win by a score of 23.8 to 23.5 with Arizona winning on the moneyline and on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on November 21, 2025 at 10:58AM ET.
img NFL

Jacksonville at Arizona

November 23, 2025
img4:05 PM Eastern

Arizona comes off two losses to Seattle and San Francisco, but it's not QB Jacoby Brissett's fault. He completed an NFL-record 47 passes for 452 yards and two TDs against the 49ers. Unfortunately, the Cardinals were called for a franchise-record 17 penalties. They are 6-1 ATS in their past seven games after allowing at least 30 points in their previous game. The Cardinals are 19-7-1 ATS after totaling fewer than 90 yards in their last game. Arizona is 8-1 ATS in its past nine against AFC opponents. Jacksonville is on a 2-18 ATS run versus NFC West teams, and although the Jaguars routed the Chargers while staying UNDER last week, they are 1-3-1 ATS their past five games. Arizona has gone UNDER in four of its past six November games, and the Cardinals are 2-9-1 UNDER as underdogs of nine or fewer points against opponents at .500 or above. Look for Arizona to cut down on its mistakes and give its defense a better chance. Take the Cardinals and the UNDER. 

Final Score

1
2
3
4
F
Jacksonville Jaguars img
7
3
7
7
27
Arizona Cardinals
7
7
0
10
24

NFL Pro Pick Results

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Losses
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Losses
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1,125
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173
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September 26, 2021 1:00pm ET
@
Arizona Cardinals
Arizona Cardinals
#469
Jacksonville Jaguars
Jacksonville Jaguars
#470

Lines & Odds

-8 (-110)
ATS
+8 (-110)
-382
Moneyline
+310
OVER 51.5 (-110)
Total
UNDER 51.5 (-110)

Public Consensus

Who was the public on? 93% of the public bets were on Arizona Cardinals on the -8 ATS. And, 53% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Arizona would win by a score of 29.1 to 20.9 with Arizona winning on the moneyline and on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on September 22, 2023 at 10:20AM ET.
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Arizona at Jacksonville

September 26, 2021
img1:00 PM Eastern

Arizona is getting enormous respect from oddsmakers and the betting public, but this is a tough situational spot. Arizona played on the East Coast in Week 1 at Tennessee, played its home opener Sunday, and now it heads back to the East Coast to Florida. They were a 4-point favorite over Minnesota, but they squeezed out a 34-33 win when the Vikings missed a late field goal. The Cardinals are 4-10 ATS as a favorite and 5-15-1 ATS after getting 250+ passing yards in their last game. This is the second straight home game for Jacksonville, and they are playing hard for Urban Meyer and the new coaching staff. Meyer likes a balanced attack, and Arizona is #25 in run defense, #30 in yards per carry (5.4) allowed. NFL favorites like Arizona are 53-97 ATS after a game with a turnover margin of minus-2 or worse, so back the home dog. Play Jacksonville.

Final Score

1
2
3
4
F
Arizona Cardinals img
7
0
17
7
31
Jacksonville Jaguars
0
13
6
0
19
November 26, 2017 4:25pm ET
@
Jacksonville Jaguars
Jacksonville Jaguars
#269
Arizona Cardinals
Arizona Cardinals
#270

Lines & Odds

-6 (-115)
ATS
+6 (-105)
-274
Moneyline
+231
OVER 37 (-108)
Total
UNDER 37 (-112)

Public Consensus

Who was the public on? 76% of the public bets were on Jacksonville Jaguars on the -6 ATS.

Computer Predictions

My computer prediction for this game was that Jacksonville would win by a score of 21.7 to 16.1 with Jacksonville winning on the moneyline, Arizona winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on November 24, 2023 at 10:54AM ET.
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Jacksonville at Arizona

November 26, 2017
img4:25 PM Eastern

The defensive advancement that this Jacksonville team has made from last year may be one of the best year-over-year upgrades we have seen in the NFL for quite some time, especially in an era where scoring is a plenty. The Jaguars gave up 25 points per game last year, but through 10 games this season they are allowing 14.1 ppg. They have held six of their opponents to nine or fewer points, and five teams to seven or fewer. The scary part is that they seem to be getting better as they have allowed just 31 total points in their last four games or less than eight points per game. The offense has done just enough to keep them in the winning column. Arizona has done very little offensively this season, and it has led to seven of their ten games playing UNDER the total. I don't see the Cardinals moving the ball much in this game, and Jacksonville will have the burden of scoring perhaps 30 points to get this one over the total - and they have only topped 30 just once time all season. Play on the UNDER.

Final Score

1
2
3
4
F
Jacksonville Jaguars
0
3
7
14
24
Arizona Cardinals img
3
10
3
11
27
November 17, 2013 1:00pm ET
@
Arizona Cardinals
Arizona Cardinals
#419
Jacksonville Jaguars
Jacksonville Jaguars
#420

Lines & Odds

-9.5 (-107)
ATS
+9.5 (-108)
-419
Moneyline
+337
OVER 40.5 (-109)
Total
UNDER 40.5 (-109)

Public Consensus

Who was the public on? 62% of the public bets were on Arizona Cardinals on the -9.5 ATS. 50% of the public money was on Jacksonville Jaguars to win on the moneyline. And, 76% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Arizona would win by a score of 22.3 to 17.1 with Arizona winning on the moneyline, Jacksonville winning on the spread and the game going UNDER the total.

Pro Picks

img NFL

Arizona at Jacksonville

November 17, 2013
img1:00 PM Eastern

The Jacksonville Jaguars finally won a game last week. Congratulations. They ended up in a shootout against Tennessee, scoring a season-high 29 points. Sometimes it takes just one game to start to believe that you can score, so I expect that the Jags don't get to 29 again here, but score more than the 11.8 points per game they were averaging before last week. The bigger problem for the Jags remains their defense which has allowed 32.3 points per game and is showing little signs of improvement. Only once this season have they held an opponent to under 24 points (and that was offensively challenged Oakland). Arizona is a much improved team over a year ago. Over the last eight weeks they are 5-3 with the losses coming to San Francisco, New Orleans and Seattle - nothing to cry about there. They are beating the teams they are supposed to beat. The offense, which had been problematic, has suddenly found its way as the Cardinals have scored 20 points or more in five straight games. Last year they scored 20+ just once in their final 12 games so this team is far advanced offensively over a year ago. The Cards have now covered six of their last seven following an ATS loss. While Jacksonville may have that satisfied feeling here, as they are 1-7-1 ATS off a win in their previous game. And home field has provided no advantage for them as they are just 2-9 ATS at home dating back to last season. Both teams seem to have a sense of offense right now, so I expect this one to play higher than expected. Go with both Arizona and the OVER.

Final Score

1
2
3
4
F
Arizona Cardinals img
7
7
10
3
27
Jacksonville Jaguars
14
0
0
0
14
September 20, 2009 1:00pm ET
@
Arizona Cardinals
Arizona Cardinals
#221
Jacksonville Jaguars
Jacksonville Jaguars
#222

Lines & Odds

+3 (-105)
ATS
-3 (-110)
+145
Moneyline
-165
OVER 44 (-110)
Total
UNDER 44 (-110)

Public Consensus

Who was the public on? 51% of the public bets were on Arizona Cardinals on the +3 ATS. 78% of the public money was on Arizona Cardinals to win on the moneyline. And, 52% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Jacksonville would win by a score of 23.3 to 22.0 with Jacksonville winning on the moneyline, Arizona winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Arizona Cardinals img
10
14
7
0
31
Jacksonville Jaguars
3
0
7
7
17

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