Previous Matchups & Picks

October 12, 2025 1:00pm ET
@
Arizona Cardinals
Arizona Cardinals
#255
Indianapolis Colts
Indianapolis Colts
#256

Lines & Odds

+9 (-110)
ATS
-9 (-110)
+337
Moneyline
-434
OVER 46.5 (-110)
Total
UNDER 46.5 (-110)

Cardinals vs. Colts Spread Picks

Get this week's Cardinals vs. Colts point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Cardinals vs. Colts.

Public Consensus

Who was the public on? 62% of the public bets were on Indianapolis Colts on the -9 ATS. And, 62% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Indianapolis would win by a score of 26.2 to 20.2 with Indianapolis winning on the moneyline, Arizona winning on the spread and the game going UNDER the total.

Final Score

1
2
3
4
F
Arizona Cardinals
7
3
14
3
27
Indianapolis Colts img
7
7
3
14
31

NFL Pro Pick Results

Here’s how my Pro Picks are performing.

NFLNFL All Picks last 25.0 years
Wins
Losses
Units
3,208
2,857
+182.36
NFLNFL Max Plays last 25.0 years
Wins
Losses
Units
1,320
1,125
+155.43
NFLNFL Free Picks last 16.6 years
Wins
Losses
Units
261
173
+99.53
NFLNFL All Preseason Picks last 24.0 years
Wins
Losses
Units
499
429
+46.95
NFLNFL All Playoff Picks last 13.1 years
Wins
Losses
Units
227
177
+42.81
NFLNFL Between teams last 10.7 years
Wins
Losses
Units
4
1
+2.31
August 17, 2024 7:00pm ET
@
Arizona Cardinals
Arizona Cardinals
#417
Indianapolis Colts
Indianapolis Colts
#418

Lines & Odds

-2.5 (-110)
ATS
+2.5 (-110)
-138
Moneyline
+116
OVER 36 (-109)
Total
UNDER 36 (-112)

Computer Predictions

My computer prediction for this game was that Arizona would win by a score of 19.3 to 16.8 with Arizona winning on the moneyline.

Pro Picks

These Pro Picks were released to clients on August 15, 2024 at 10:53AM ET.
img NFL

Arizona at Indianapolis

August 17, 2024
img7:00 PM Eastern

Arizona lost in the final seconds 16-14 as Charlie Smyth kicked a 37-yard field goal to give New Orleans a 16-14 win in Week 1. Clayton Tune was 15 of 24 for 163 yards, a TD for the Cardinals, and Desmond Ridder finished 4 of 9 for 43 yards. Kyler Murray is not expected to play in the preseason. The Cardinals held the Saints to just 185 yards passing, although Arizona had just 183 itself, and the game went UNDER by eight points. Jonathan Gannon has gone UNDER in three of his four preseason games as coach of the Cardinals, averaging 15 points per game. Indianapolis lost 34-30 to Denver, and the Colts are 5-9 ATS in their past 14 games as preseason home favorites. The Colts saw five quarterbacks in action, including Sam Ehlinger, Jason Bean, Kedon Slovis, Joe Flacco, and Anthony Richardson. They combined for 17 of 26 for only 219 yards, and the Colts rushed for just 64 yards on 2.8 yards per carry. Take the points with the Cardinals as a Max Play and the UNDER in a low-scoring affair.

Final Score

1
2
3
4
F
Arizona Cardinals
0
10
3
0
13
Indianapolis Colts img
7
0
7
7
21
December 25, 2021 8:15pm ET
@
Indianapolis Colts
Indianapolis Colts
#455
Arizona Cardinals
Arizona Cardinals
#456

Lines & Odds

+3 (+100)
ATS
-3 (-120)
+143
Moneyline
-164
OVER 48 (-110)
Total
UNDER 48 (-110)

Public Consensus

Who was the public on? 55% of the public bets were on Indianapolis Colts on the +3 ATS. And, 55% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Indianapolis would win by a score of 25.1 to 24.4 with Indianapolis winning on the moneyline and on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on December 22, 2023 at 12:51PM ET.
img NFL

Indianapolis at Arizona

December 25, 2021
img8:15 PM Eastern

Two teams going in different directions meet on Saturday as Indianapolis has won five of its last six games, and Arizona has lost four of seven after starting the season 7-0. The Cardinals obviously overachieved a bit earlier in the season, and teams have since learned how to defend Kyler Murray, who finished 23 of 41 for 257 yards with a touchdown and interception in Detroit's giant upset of the Cardinals last week. The defense looks suspect, also, as the Lions drove 63 yards to start the game that led to a field goal. Jared Goff picked apart the Arizona secondary, completing 21 of 26 for 216 yards and three TDs. The Colts dominated New England, and the game wasn't as close as the 27-17 final indicates. Indianapolis averages 28.4 points this season, and that is third in the league. The defense is also 15th in total yards allowed. The Cardinals have averaged barely 20 points their last five games, and they went UNDER by 6.5 points against Detroit. Arizona will have to deal with Jonathan Taylor, who has rushed for 1,854 yards, including 170 against the Patriots. The Colts are 29-12 UNDER their past 41 December games, and Arizona has stayed UNDER five of six following a loss. Play the Colts on the moneyline and the UNDER.

Final Score

1
2
3
4
F
Indianapolis Colts img
7
5
3
7
22
Arizona Cardinals
6
0
7
3
16
September 17, 2017 1:00pm ET
@
Arizona Cardinals
Arizona Cardinals
#269
Indianapolis Colts
Indianapolis Colts
#270

Lines & Odds

-6.5 (-110)
ATS
+6.5 (-110)
-298
Moneyline
+247
OVER 44 (-105)
Total
UNDER 44 (-115)

Public Consensus

Who was the public on? 77% of the public bets were on Arizona Cardinals on the -6.5 ATS. 57% of the public money was on Arizona Cardinals to win on the moneyline. And, 50% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that Arizona would win by a score of 25.1 to 21.9 with Arizona winning on the moneyline, Indianapolis winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
O
F
Arizona Cardinals img
0
3
0
10
3
16
Indianapolis Colts
10
0
0
3
0
13
November 24, 2013 4:05pm ET
@
Indianapolis Colts
Indianapolis Colts
#227
Arizona Cardinals
Arizona Cardinals
#228

Lines & Odds

+3 (+105)
ATS
-3 (-123)
+160
Moneyline
-182
OVER 44 (-110)
Total
UNDER 44 (-108)

Public Consensus

Who was the public on? 56% of the public bets were on Indianapolis Colts on the +3 ATS. 67% of the public money was on Indianapolis Colts to win on the moneyline. And, 83% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Arizona would win by a score of 22.5 to 21.9 with Arizona winning on the moneyline, Indianapolis winning on the spread and the game going OVER the total.

Pro Picks

img NFL

Indianapolis at Arizona

November 24, 2013
img4:05 PM Eastern

While the Arizona Cardinals are getting into the playoffs hunt, the Indianapolis Colts are at 7-3 and likely to make their second straight appearance with Andrew Luck at QB. Arizona has become a player with three straight wins, pulling them to 6-4. QB Carson palmer is hard to live with sometimes, but the reality is, the Cards offense has been much better with him. If you look at Arizona's last 12 games a year ago, they scored 20 points or more just once. This season with Carson at QB, the Cards have scored 20+ in 8 of 10 games, including each of their last six. The defense has played well, but against winning teams they have allowed 24.8 ppg and if you take out the Carolina game (before the Panthers started clicking), it is 29.5 ppg. Indy has scored 20+ in 16 of their last 19 games, so I expect both sides to get over the 20 mark in this game. Arizona is 66-29-1 to the OVER in their last 96 games after totaling more than 350 yards in their last one. Make the play on the OVER.

Final Score

1
2
3
4
F
Indianapolis Colts
3
0
0
8
11
Arizona Cardinals img
7
20
7
6
40

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