Arizona Cardinals vs Carolina Panthers Point Spread Picks

Carolina has had great success against the Cardinals, winning seven of eight outright with a 7-1 ATS record. The Panthers won last year's meeting in overtime 36-30 when Bryce Young had one of his better games, finishing 17 of 26 for 158 yards and two TDs with no picks. Carolina comes off a 26-10 loss to Jacksonville, but the Panthers still are on a 7-3 ATS run dating to last season. They have gone UNDER four straight in Week 2, and last week's game stayed UNDER by nine points. The Jaguars played a near-perfect game, both fundamentally and strategically, as they didn't yield a sack or a turnover. Meanwhile, Arizona took advantage of 13 penalties for 89 yards by New Orleans, and the Cardinals still had to turn back a drive by the Saints in the final two minutes to win 20-13. What's more, Kyler Murray was sacked five times, and the Cardinals were outgained 315-276. Take the Panthers and the UNDER.

Arizona snapped a three-game skid, but it was against the lowly Patriots, who didn't score a touchdown until the fourth quarter. The Cardinals have a bad history against Carolina, with a 1-6 ATS record in the past seven meetings and losing six outright. Arizona is 4-14 ATS in its last 18 road games and has lost four of five against NFC opponents. The Panthers have covered the number five of their past six games, including taking Kansas City and Philadelphia to the wire. Bryce Young finished 19 of 28 for 219 yards but was victimized by two interceptions as the Panthers lost 30-14 to Dallas last week. Arizona has averaged only 19 points in its past four games, and the Cardinals are banged up on defense as they lost two starting linebackers in the game's first five plays against New England. Take the Panthers.

Arizona is picking up where it left off in 2021 when it had an 8-2 ATS record on the road and 2-6 ATS at home. The Cardinals won their only road game this season and they have lost both home contests, including 20-12 to the Rams last week. Kyler Murray threw for 314 yards and wide receiver Marquise Brown had 14 catches for 140 yards for Arizona, which outgained the Rams 365-339. The Cardinals go on the road this week against Carolina, which got its first win in 10 games dating to last season 22-14 over New Orleans. The Panthers though were fortunate as defensive end Marquis Haynes returned a fumble 44 yards for a touchdown and Laviska Shenault caught a 67-yard TD pass from Baker Mayfield, who completed only 12 of 25 for 170 yards. However, Shenault is doubtful for this game with a hamstring injury and Christian McCaffrey, as usual, is questionable. Also, Haynes is questionable with a knee injury. The Cardinals are 7-1 ATS their past eight October games and 19-7-2 ATS their past 28 road games. Carolina is 3-14 ATS its past 17 games overall and 7-19-1 ATS at home. Take the Cardinals ATS as a Max Play.

Running the football chews up yards and the clock, and both teams will look to run. Carolina will run because star RB Christian McCaffrey came back last week and looked good. They'll also focus on running because the team can't pass, stuck with QB Sam Darnold (7 TDs, 11 INTS), who looks worse each week. Carolina (7-2 UNDER the total) has scored 28 total points in the last three games. While Carolina is on a 10-3 run UNDER, three of Arizona's four home games have gone UNDER. QB Kyler Murray, RB James Conner, and RB Chase Edmonds lead the ninth-ranked rushing attack in the NFL (fourth-best in the NFC), while the Cardinals' defense is No. 4 in yards allowed, No. 3 in points surrendered (17.2 pg), and No. 2 on third-down (31.73%). And winning NFL teams like Arizona that come off a division win are 32-11 UNDER the total against losing teams. Play the UNDER.