San Francisco Giants vs St. Louis Cardinals Betting Picks

Cardinals vs. Giants Betting Picks

Get Cardinals vs. Giants betting picks, expert betting analysis, computer model picks, betting consensus data, matchup breakdowns, key betting angles, and the latest odds insights for today's Cardinals vs. Giants game.

Computer Predictions

My computer prediction for this game is that St. Louis will win by a score of 0.0 to 0.0.

Computer Predictions

My computer prediction for this game is that St. Louis will win by a score of 0.0 to 0.0.

Computer Predictions

My computer prediction for this game is that St. Louis will win by a score of 0.0 to 0.0.

Public Consensus

Who was the public on? 57% of the public money was on St. Louis Cardinals to win on the moneyline. And, 66% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that St. Louis would win by a score of 4.5 to 3.9 with St. Louis winning on the moneyline, San Francisco winning on the runline and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on September 24, 2025 at 11:39AM ET.

MLB

St. Louis at San Francisco

September 24, 2025

9:45 PM Eastern

St. Louis has won the first two of this series, 6-5 and 9-8. Starter Sonny Gray has a 5.11 ERA on the road this season, along with a 5.06 ERA against the Giants. The OVER is 8-5 in his last 13 starts. San Francisco is on a 14-8-3 run OVER the total. 33-year-old starter Robbie Ray has been hit hard in his last two starts (11 hits, 10 runs, 6 walks, in 8+ innings), losses of 6-3 and 10-2. The OVER is 4-0-1 in his last five starts. Take St. Louis/San Francisco OVER the total. 

Final Score

1

2

3

4

5

6

7

8

9

R

St. Louis Cardinals

0

0

2

0

0

0

0

1

0

3

San Francisco Giants

0

1

1

1

0

0

0

1

4

Public Consensus

Who was the public on? 65% of the public money was on San Francisco Giants to win on the moneyline. And, 65% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that San Francisco would win by a score of 4.5 to 3.8 with San Francisco winning on the moneyline, St. Louis winning on the runline and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on September 23, 2025 at 10:48AM ET.

MLB

St. Louis at San Francisco

September 23, 2025

9:45 PM Eastern

St. Louis has won five of eight after taking the first game of this series, 6-5, as a +125 underdog. Andre Pallante has a 3.00 ERA against the Giants this season in a 3-2 victory three starts ago. The bullpen is sixth in the majors with a 3.60 ERA. The Cardinals are also 5-2 in their last seven as an underdog or at even money. Meanwhile, San Francisco is on a 5-11 slide, including 1-3 in their last four as a favorite. The offense is 17th in runs scored, 21st in on-base percentage, 29th in steals, and 26th in slugging. The defense ranks 25th in fielding percentage. The Giants have lost the last two starts made by Logan Webb (eight runs, 14 hits allowed, in 11 innings). Play St. Louis. 

Final Score

1

2

3

4

5

6

7

8

9

R

St. Louis Cardinals

3

0

0

0

0

0

4

0

2

9

San Francisco Giants

0

0

5

0

2

1

0

0

0

8