St. Louis has won five of eight after taking the first game of this series, 6-5, as a +125 underdog. Andre Pallante has a 3.00 ERA against the Giants this season in a 3-2 victory three starts ago. The bullpen is sixth in the majors with a 3.60 ERA. The Cardinals are also 5-2 in their last seven as an underdog or at even money. Meanwhile, San Francisco is on a 5-11 slide, including 1-3 in their last four as a favorite. The offense is 17th in runs scored, 21st in on-base percentage, 29th in steals, and 26th in slugging. The defense ranks 25th in fielding percentage. The Giants have lost the last two starts made by Logan Webb (eight runs, 14 hits allowed, in 11 innings). Play St. Louis.
This Pro Pick was released to clients on September 23, 2025 at 10:48AM ET.
St. Louis at San Francisco
September 23, 2025
2 units on St. Louis +178 (moneyline) (risk 2 to return 5.56)
Result:
WIN
WIN
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