San Diego is on a 10-7-1 run UNDER the total with an offense that is 18th in runs scored, 18th in steals, and 23rd in slugging. Michael King (3.84 ERA) is holding batters to a .228 average, while the bullpen is No. 1 in the majors with a 3.07 ERA. Chicago's offense is 26th in runs scored, 27th in on-base percentage, 24th in steals, and 29th in slugging. Sean Burke has a 3.93 ERA at home and has 119 Ks in 126 innings overall. He's allowed two earned runs or less in 15 of his last 20 starts. The White Sox are on a 7-2 run UNDER the total. Take San Diego/Chicago UNDER the total.
This Pro Pick was released to clients on September 21, 2025 at 9:24AM ET.
MLB
San Diego at Chicago
September 21, 2025
2:10 PM Eastern
1 unit on Game Total UNDER 8.5 -125 (risk 1 to return 1.8)
Result:
WIN
WIN
TAKE THE GUESSWORK OUT OF SPORTS BETTING
Get free MLB Picks
I pore over the data, injuries, news, and odds every morning.
You get the best bets delivered to your inbox.