This Pro Pick was released to clients on April 22, 2026 at 11:05AM ET.
img MLB

Los Angeles at San Francisco

April 22, 2026
img9:45 PM Eastern

There are times when the price is inflated enough, and the situation is good, where you can go against the Dodgers. This is one of those opportunities backing the home Giants at a huge underdog price. Forget the Giants beginning the season 6-12. They are 4-1 in their last five games and just beat the Dodgers 3-1 on Tuesday night, holding LA to three hits. The Dodgers have a couple of key injuries with Mookie Betts out with a back injury and closer Edwin Diaz sidelined long-term with an elbow injury. The pitching matchup looks lopsided, with Shohei Ohtani (2-0, 0.50 ERA) going against Tyler Mahle (0-3, 7.23 ERA), which is driving the price. Ohtani's pitching numbers are great, but unsustainable. He had a 2.87 ERA last season. Mahle’s due for positive regression after posting a 2.18 ERA across 16 starts last year. Take the Giants. 

1 unit on San Francisco +187 (moneyline) (risk 1 to return 2.87)
Result:
WIN
Final
1
2
3
4
5
6
7
8
9
R
Los Angeles Dodgers
0
0
0
0
0
0
0
0
0
0
San Francisco Giants img
0
0
0
0
0
0
3
0
3
consensus consensus
odds odds
 
TAKE THE GUESSWORK OUT OF SPORTS BETTING

Get free MLB Picks

I pore over the data, injuries, news, and odds every morning.
You get the best bets delivered to your inbox.