Philadelphia has lost two straight, but it is still 16-7 since Don Mattingly took over as manager and back in the wild-card race. The Phillies have won 14 of their past 20 against American League teams. They have averaged 5.5 runs in their past six games as their hitting has also come around since Mattingly took the helm. The Phillies will look to end Cleveland's six-game win streak, which was aided by playing four games against the weak-hitting Tigers, who scored eight runs in the entire series. Christopher Sanchez is 5-2 with a 1.82 ERA, and the Phillies have won his past four starts. Sanchez has not allowed a run in three outings, including a complete-game 6-0 victory over Pittsburgh on Saturday. He has also gotten great run support, as the combined score of his past four starts is 24-3. Take the Phillies.
This Pro Pick was released to clients on May 22, 2026 at 11:34AM ET.
Cleveland at Philadelphia
May 22, 2026
2 units on Philadelphia -159 (moneyline) (risk 2 to return 3.26)
Result:
LOSS
LOSS
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