Chicago lost two of three at Dodger Stadium, but that's understandable, and the Cubs previously had won 10 in a row. San Diego has split its past four games, but it has allowed 32 runs in that span, including a 12-7 loss to the Diamondbacks on Sunday. The Padres are home following an eight-game trip and will start Randy Vasquez, who is off to a good start in 2026, but he has actually pitched better on the road. Vasquez has allowed five runs on 14 hits in 15 2/3 innings at home. The Cubs will counter with Matthew Boyd, who has given up four runs in 10 1/3 innings in his past two outings, and Chicago won both. San Diego's bullpen surrendered 10 runs on 12 hits in two innings yesterday. Take the Cubs.
This Pro Pick was released to clients on April 27, 2026 at 1:59PM ET.
Chicago at San Diego
April 27, 2026
2 units on Chicago +106 (moneyline) (risk 2 to return 4.12)
Result:
LOSS
LOSS
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