Arizona at Seattle

Arizona has a losing road record and has been stumbling on offense the last four weeks. This is a tough situational spot for the Diamondbacks, the second road game of a 10-game trip. Meanwhile Seattle is 2-2 on its six-game homestand at Safeco Field. Arizona got the win in the opener of this series, 4-3, but Seattle's Robinson Cano went 2-for-3 with a solo homer and Mark Trumbo collected three hits. The Mariners are 18-5 following a loss, plus 14-5 in interleague games as a favorite of -151 to -200. Mariners veteran Hisashi Iwakuma (2-1) looks healthy and has thrown three straight strong outings. The Mariners are 7-2 when Iwakuma faces a team with a losing record, as well as 7-2 when he gets four days of rest. Seattle has owned this series at 8-3 over the last 11 meetings, with the Diamondbacks 1-4 at Safeco Field. Play on Seattle.