San Diego got shut out by the Dodgers earlier this week, and that same finishing trouble has followed the rotation into the weekend. Casey Mize's 3.96 ERA still looks clean on the season, but the pitcher taking the mound right now has allowed 14 earned runs across his last four turns, including five in three innings in his most recent outing. Arizona arrives as the league's hottest team not named the Dodgers, winners of five straight and coming off a 12-8 shootout that had both bullpens working overtime. Brandon Pfaadt has been the steadier arm of the two by the numbers, and after getting rocked for six runs two starts back, he answered with a clean four-and-a-third innings, one run allowed, in his last outing. The professional money backs the read: Arizona's moneyline is pulling the bulk of the dollars on a fraction of the tickets, the clearest signal on the board tonight. A club playing its best baseball of the season, catching plus money against a starter who just got hit hard, is exactly the kind of number I want on the moneyline, and with both offenses rolling and both staffs stretched thin down the stretch, I like the total to follow the same shape. Take Arizona on the moneyline and take the OVER tonight.
These Pro Picks were released to clients on September 25, 2026 at 12:26PM ET.
Arizona at San Diego
September 25, 2026
1.5 units on Arizona +121 (moneyline) (risk 1.5 to return 3.32)
Result:
WIN
WIN
2 units on Game Total OVER 7.5 -108 (risk 2 to return 3.85)
Result:
WIN
WIN
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