Chicago White Sox vs San Diego Padres Betting Picks

Chicago goes for its sixth win in a row and a sweep of the three-game series with the Padres after its 4-0 victory on Saturday. Miguel Vargas hit a go-ahead two-run single in the sixth and San Diego was held to six hits as the game easily stayed UNDER. The Padres have gone UNDER four straight after scoring two or fewer runs their previous game. Chicago has stayed UNDER six of nine and it has won five of its past six road games. Griffin Canning is scheduled to make his first start of the season for the Padres following a 10-month rehab from a left Achilles tear. He had a 3.77 ERA with the Mets in 2025 before he was injured in June. San Diego has lost four in a row while scoring a total of only nine runs. Take the White Sox and the UNDER.

Chicago has won nine of 12, after sweeping the Angels and beating the Padres yesterday, 8-2, as an underdog. The offense is 13th in the majors in steals, and they've won four in a row, tallying 24 runs. Sean Burke (3.21 ERA) is holding batters to a .226 average. He won at Arizona, 11-5, in his last road start as a +130 dog. San Diego's offense is 16th in runs scored, 25th in on-base percentage, and 18th in slugging. They've lost four of five, surrendering 40 runs, while the bullpen ranks 16th with a 4.09 ERA. San Diego has dropped three of its last four in the role of favorite. Play Chicago.

Chicago has won eight of 12 after sweeping the Angels. 22-year-old Noah Schultz (3.52 ERA) is holding batters to a .151 average, and sports a 1.80 ERA on the road. The offense is 12th in the majors in steals. San Diego's offense is 15th in runs scored, 26th in on-base percentage, and 16th in slugging. They've lost three of four, surrendering 32 runs. German Marquez (4.38 ERA) has a 9.00 ERA at home, and the bullpen ranks 20th in ERA (4.15). Play Chicago.

San Diego is on a 10-7-1 run UNDER the total with an offense that is 18th in runs scored, 18th in steals, and 23rd in slugging. Michael King (3.84 ERA) is holding batters to a .228 average, while the bullpen is No. 1 in the majors with a 3.07 ERA. Chicago's offense is 26th in runs scored, 27th in on-base percentage, 24th in steals, and 29th in slugging. Sean Burke has a 3.93 ERA at home and has 119 Ks in 126 innings overall. He's allowed two earned runs or less in 15 of his last 20 starts. The White Sox are on a 7-2 run UNDER the total. Take San Diego/Chicago UNDER the total.