The Notre Dame Fighting Irish will put their #9 ranking on the line as they head to Pittsburgh to take on the #23-ranked Panthers. The Irish have a great offense, but Pittsburgh has a great defense that allows just 318 yards per game at 4.7 yards per play. The Irish will be forced to be a one-dimensional team as the Panthers are allowing just 2.4 yards per carry and 81 rushing yards per game. The Irish opened the season allowing 98 points in their first three games, or 32.7 points per game, but over their last six games, they have allowed just 71 points, or 11.8 points per game. I don't expect this to be a high-scoring game, as both defenses are rock-solid. Make the play UNDER the total.
Previous Matchups & Picks
November 15, 2025 12:00pm ET
@
Notre Dame Fighting Irish
#351
Pittsburgh Panthers
#352
Lines & Odds
-13 (-110)
ATS
+13 (-110)
-503
Moneyline
+379
OVER 55 (-110)
Total
UNDER 55 (-110)
Fighting Irish vs. Panthers Spread Picks
Get this week's Fighting Irish vs. Panthers point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Fighting Irish vs. Panthers.
Public Consensus
Who was the public on? 59% of the public bets were on Pittsburgh Panthers on the +13 ATS. And, 64% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 35.9 to 21.7 with Notre Dame winning on the moneyline and on the spread and the game going OVER the total.
Pro Picks
This Pro Pick was released to clients on November 13, 2025 at 11:28AM ET.
CFB
Notre Dame at Pittsburgh
November 15, 2025
12:00 PM Eastern
Final Score
1
2
3
4
F
Notre Dame Fighting Irish 
14
7
9
7
37
Pittsburgh Panthers
0
3
6
6
15
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October 28, 2023 3:30pm ET
@
Pittsburgh Panthers
#183
Notre Dame Fighting Irish
#184
Lines & Odds
+21 (-110)
ATS
-21 (-110)
+821
Moneyline
-1455
OVER 45.5 (-115)
Total
UNDER 45.5 (-110)
Public Consensus
Who was the public on? 53% of the public bets were on Pittsburgh Panthers on the +21 ATS. And, 66% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 37.3 to 14.2 with Notre Dame winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
Pittsburgh Panthers
0
0
0
7
7
Notre Dame Fighting Irish
7
10
27
14
58
October 24, 2020 3:30pm ET
@
Notre Dame Fighting Irish
#317
Pittsburgh Panthers
#318
Lines & Odds
-10 (-110)
ATS
+10 (-110)
-402
Moneyline
+308
OVER 43.5 (-110)
Total
UNDER 43.5 (-110)
Public Consensus
Who was the public on? 51% of the public bets were on Notre Dame Fighting Irish on the -10 ATS. And, 66% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 28.0 to 17.7 with Notre Dame winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
Notre Dame Fighting Irish
7
21
17
0
45
Pittsburgh Panthers
3
0
0
0
3
October 13, 2018 2:30pm ET
@
Pittsburgh Panthers
#153
Notre Dame Fighting Irish
#154
Lines & Odds
+21 (-110)
ATS
-21 (-110)
+927
Moneyline
-1475
OVER 55.5 (-110)
Total
UNDER 55.5 (-110)
Public Consensus
Who was the public on? 62% of the public bets were on Notre Dame Fighting Irish on the -21 ATS. 51% of the public money was on Notre Dame Fighting Irish to win on the moneyline. And, 77% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 36.6 to 18.1 with Notre Dame winning on the moneyline, Pittsburgh winning on the spread and the game going UNDER the total.
Final Score
1
2
3
4
F
Pittsburgh Panthers
7
0
7
0
14
Notre Dame Fighting Irish
0
6
6
7
19
November 7, 2015 12:00pm ET
@
Notre Dame Fighting Irish
#405
Pittsburgh Panthers
#406
Lines & Odds
-9 (-115)
ATS
+9 (-105)
-344
Moneyline
+278
OVER 53 (-110)
Total
UNDER 53 (-110)
Public Consensus
Who was the public on? 65% of the public bets were on Notre Dame Fighting Irish on the -9 ATS. And, 54% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 33.5 to 24.2 with Notre Dame winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
Notre Dame Fighting Irish
7
14
7
14
42
Pittsburgh Panthers
3
0
14
13
30
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