Oregon makes its first road trip of the season after two blowout wins at home. Northwestern plays its second straight at home. After a bad opener, new QB Preston Stone was terrific in a 42-7 rout of Western Illinois. The senior came over from SMU, where he threw 33 touchdowns and seven interceptions from 2023 to 2024. The defense is the strength of the team, capable of rushing the passer with Aidan Hubbard and NFL prospect Anto Saka. Northwestern was a +28 home underdog to No. 2 Ohio State last year. They covered and have a better offense this season. Play Northwestern.
Previous Matchups & Picks
September 13, 2025 12:00pm ET
@
Oregon Ducks
#117
Northwestern Wildcats
#118
Lines & Odds
-25 (-110)
ATS
+25 (-110)
-5580
Moneyline
+1634
OVER 50 (-110)
Total
UNDER 50 (-110)
Ducks vs. Wildcats Spread Picks
Get this week's Ducks vs. Wildcats point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Ducks vs. Wildcats.
Public Consensus
Who was the public on? 76% of the public bets were on Oregon Ducks on the -25 ATS. And, 71% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Oregon would win by a score of 38.3 to 10.0 with Oregon winning on the moneyline and on the spread and the game going UNDER the total.
Pro Picks
This Pro Pick was released to clients on September 11, 2025 at 10:17AM ET.
CFB
Oregon at Northwestern
September 13, 2025
12:00 PM Eastern
Final Score
1
2
3
4
F
Oregon Ducks 
7
10
14
3
34
Northwestern Wildcats
0
0
0
14
14
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