This game looks like an old Rose Bowl battle as Michigan takes on USC on the road. This is a massive game in the Big-10 as both teams enter at 4-1, and the winner will certainly gain points to be in the playoffs come season's end. This is going to be a battle of the Michigan elite defense vs. the Trojans' elite passing game that so far has generated 11ypa. The Michigan defense has already forced nine turnovers this season, while the Wolverines have committed three turnovers all season. I think the tight line in this game is justified, but in the end, you have to make stops, and clearly, Michigan has proven to be able to do so. Make the play on Michigan on the moneyline.
Previous Matchups & Picks
October 11, 2025 7:30pm ET
@
Michigan Wolverines
#171
USC Trojans
#172
Lines & Odds
+3 (-110)
ATS
-3 (-110)
+133
Moneyline
-155
OVER 58 (-110)
Total
UNDER 58 (-110)
Wolverines vs. Trojans Spread Picks
Get this week's Wolverines vs. Trojans point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Wolverines vs. Trojans.
Public Consensus
Who was the public on? 64% of the public bets were on USC Trojans on the -3 ATS. And, 59% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that USC would win by a score of 30.4 to 27.7 with USC winning on the moneyline, Michigan winning on the spread and the game going OVER the total.
Pro Picks
This Pro Pick was released to clients on October 09, 2025 at 12:13PM ET.
CFB
Michigan at USC
October 11, 2025
7:30 PM Eastern
Final Score
1
2
3
4
F
Michigan Wolverines
0
7
0
6
13
USC Trojans 
7
7
7
10
31
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All Picks last 13.7 years
Wins
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228
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September 21, 2024 3:30pm ET
@
USC Trojans
#387
Michigan Wolverines
#388
Lines & Odds
-4 (-110)
ATS
+4 (-110)
-179
Moneyline
+156
OVER 44 (-115)
Total
UNDER 44 (-110)
Public Consensus
Who was the public on? 69% of the public bets were on USC Trojans on the -4 ATS. And, 52% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that Michigan would win by a score of 26.7 to 24.9 with Michigan winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
USC Trojans
0
3
14
7
24
Michigan Wolverines
7
7
6
7
27
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