Michigan State lost seven of its final nine games last season. They're 3-0 in 2025, but haven't been that impressive (0-3 ATS). They've beaten Western Michigan (23-6) and Youngstown (41-24), while needing double overtime to survive against Boston College (42-40), allowing 457 yards. All those games were at home, and now they fly to the West Coast. Michigan State is on a 7-17-1 ATS run. No. 25 USC's offense is scorching, No. 1 in the country, averaging 55 points and 604 yards. USC is on a 12-7 ATS run, and the visitors don't have the offense to keep pace. Play USC.
Previous Matchups & Picks
September 20, 2025 11:00pm ET
@
Michigan State Spartans
#361
USC Trojans
#362
Lines & Odds
+18.5 (-110)
ATS
-18.5 (-110)
+620
Moneyline
-944
OVER 55.5 (-110)
Total
UNDER 55.5 (-110)
Spartans vs. Trojans Spread Picks
Get this week's Spartans vs. Trojans point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Spartans vs. Trojans.
Public Consensus
Who was the public on? 57% of the public bets were on USC Trojans on the -18.5 ATS. And, 68% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that USC would win by a score of 37.2 to 19.1 with USC winning on the moneyline, Michigan State winning on the spread and the game going OVER the total.
Pro Picks
This Pro Pick was released to clients on September 18, 2025 at 10:19AM ET.
CFB
Michigan State at USC
September 20, 2025
11:00 PM Eastern
Final Score
1
2
3
4
F
Michigan State Spartans
7
3
14
7
31
USC Trojans 
10
14
7
14
45
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