Previous Matchups & Picks

October 17, 2026 7:30pm ET
@
Louisville Cardinals
Louisville Cardinals
#125
Syracuse Orange
Syracuse Orange
#126

Lines & Odds

-14.5 (-110)
ATS
+14.5 (-110)
-645
Moneyline
+475
OVER 57 (-110)
Total
UNDER 57 (-110)

Cardinals vs. Orange Spread Picks

Get this week's Cardinals vs. Orange point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Cardinals vs. Orange.

Public Consensus

Who was the public on? 55% of the public bets were on Syracuse Orange on the +14.5 ATS. 99% of the public money was on Louisville Cardinals to win on the moneyline. And, 53% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 34.9 to 21.3 with Louisville winning on the moneyline, Syracuse winning on the spread and the game going UNDER the total.

Pro Picks

This Pro Pick was released to clients on October 15, 2026 at 1:00PM ET.
img CFB

Louisville at Syracuse

October 17, 2026
img7:30 PM Eastern

Louisville scored 44 on Florida State last Friday and gained 537 yards while allowing 362. It is 3-3, and it lost its three games by three points: 41-38 to Ole Miss, 30-27 to Wake Forest, and 31-28 at NC State. Louisville scores 39.5 points per game, 16th among the 138 FBS teams, and has scored 27 or more in every game this season. It gains 495 yards per game and has taken the ball away nine times while losing it four. It allows 27.7 points per game, tied for 103rd. Syracuse is 2-3, scores 32.8 points per game (53rd), and allows 24 points per game (tied for 74th). It allows 311 yards per game. It lost 28-25 at Virginia last Saturday, and it lost 21-18 to Cal and 27-13 at Pittsburgh before that. Its two wins were 66-3 over New Hampshire and 42-41 at UConn. Syracuse has lost the ball seven times in five games and taken it away six times, and Louisville ATS is the bet Saturday night. 

Final Score

1
2
3
4
F
Louisville Cardinals img
14
14
0
6
34
Syracuse Orange
10
13
0
3
26

CFB Pro Pick Results

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Losses
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240
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September 3, 2022 8:00pm ET
@
Louisville Cardinals
Louisville Cardinals
#169
Syracuse Orange
Syracuse Orange
#170

Lines & Odds

-5.5 (-110)
ATS
+5.5 (-110)
-214
Moneyline
+178
OVER 55.5 (-110)
Total
UNDER 55.5 (-110)

Public Consensus

Who was the public on? 67% of the public bets were on Louisville Cardinals on the -5.5 ATS. And, 57% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 31.8 to 26.1 with Louisville winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Louisville Cardinals
7
0
0
0
7
Syracuse Orange img
10
7
0
14
31
November 13, 2021 12:00pm ET
@
Syracuse Orange
Syracuse Orange
#141
Louisville Cardinals
Louisville Cardinals
#142

Lines & Odds

+3 (+105)
ATS
-3 (-115)
+141
Moneyline
-162
OVER 55.5 (-110)
Total
UNDER 55.5 (-110)

Public Consensus

Who was the public on? 59% of the public bets were on Louisville Cardinals on the -3 ATS. And, 55% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 29.4 to 26.7 with Louisville winning on the moneyline, Syracuse winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Syracuse Orange
3
0
0
0
3
Louisville Cardinals img
14
21
3
3
41
November 20, 2020 7:00pm ET
@
Syracuse Orange
Syracuse Orange
#325
Louisville Cardinals
Louisville Cardinals
#326

Lines & Odds

+20 (-110)
ATS
-20 (-115)
+697
Moneyline
-1115
OVER 55.5 (-110)
Total
UNDER 55.5 (-115)

Public Consensus

Who was the public on? 65% of the public bets were on Syracuse Orange on the +20 ATS. And, 65% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 37.9 to 20.1 with Louisville winning on the moneyline, Syracuse winning on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Syracuse Orange
0
0
0
0
0
Louisville Cardinals img
3
17
7
3
30
November 23, 2019 4:00pm ET
@
Syracuse Orange
Syracuse Orange
#191
Louisville Cardinals
Louisville Cardinals
#192

Lines & Odds

+7.5 (-110)
ATS
-7.5 (-110)
+346
Moneyline
-295
OVER 64.5 (-110)
Total
UNDER 64.5 (-110)

Public Consensus

Who was the public on? 65% of the public bets were on Louisville Cardinals on the -7.5 ATS. And, 57% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 38.0 to 28.0 with Louisville winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Syracuse Orange
3
7
17
7
34
Louisville Cardinals img
21
7
21
7
56

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