Previous Matchups & Picks

November 29, 2025 12:00pm ET
@
Kentucky Wildcats
Kentucky Wildcats
#353
Louisville Cardinals
Louisville Cardinals
#354

Lines & Odds

pick (-115)
ATS
pick (-105)
-104
Moneyline
-115
OVER 45.5 (-110)
Total
UNDER 45.5 (-110)

Wildcats vs. Cardinals Spread Picks

Get this week's Wildcats vs. Cardinals point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Wildcats vs. Cardinals.

Public Consensus

Who was the public on? 62% of the public bets were on Louisville Cardinals on the 0 ATS. And, 52% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 26.2 to 21.3 with Louisville winning on the moneyline and on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on November 27, 2025 at 10:33AM ET.
img CFB

Kentucky at Louisville

November 29, 2025
img12:00 PM Eastern

It's not just the Governor's Cup that is on the line for Kentucky in this in-state rivalry match-up against Louisville. The 5-6 Wildcats need to win here to become Bowl eligible. That's a big deal for Kentucky. The Wildcats had put a late stretch hot streak to get into this position, beating Tennessee Tech, 42-10, upsetting Florida at home in smashing fashion, 38-7, and upsetting Auburn, 10-3, as an 11-point road underdog. But Kentucky's win streak was halted by Vanderbilt, 45-17, on the road last week. Now the Wildcats go from playing one of the better teams in the SEC to a middle-of-the-road ACC team. In other words, a step down. The Cardinals are in a late-season rut, losers of three in a row. They've scored only 51 combined points in these three games, all losses: SMU (38-6), Clemson (20-19), and California (29-26 in overtime), as an 18.5-point home favorite. The Cardinals are the more banged-up team, too, hit hard at the skill positions. Their top three running backs - Isaac Brown, Keyjuan Brown, and Duke Watson - are out, along with their top wide receiver, Chris Bell, who leads Louisville with 917 receiving yards and six touchdown catches. In addition, quarterback Miller Moss is questionable. Take Kentucky. 

Final Score

1
2
3
4
F
Kentucky Wildcats
0
0
0
0
0
Louisville Cardinals img
7
13
7
14
41

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November 30, 2024 12:00pm ET
@
Louisville Cardinals
Louisville Cardinals
#415
Kentucky Wildcats
Kentucky Wildcats
#416

Lines & Odds

-4.5 (-115)
ATS
+4.5 (-105)
-197
Moneyline
+166
OVER 49.5 (-110)
Total
UNDER 49.5 (-110)

Public Consensus

Who was the public on? 52% of the public bets were on Kentucky Wildcats on the +4.5 ATS. And, 51% of the bets were on the game to go UNDER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 27.8 to 22.1 with Louisville winning on the moneyline and on the spread and the game going OVER the total.

Final Score

1
2
3
4
F
Louisville Cardinals img
7
13
14
7
41
Kentucky Wildcats
0
0
7
7
14
November 25, 2023 12:00pm ET
@
Kentucky Wildcats
Kentucky Wildcats
#147
Louisville Cardinals
Louisville Cardinals
#148

Lines & Odds

+7.5 (-115)
ATS
-7.5 (-110)
+237
Moneyline
-298
OVER 48 (-110)
Total
UNDER 48 (-110)

Public Consensus

Who was the public on? 63% of the public bets were on Louisville Cardinals on the -7.5 ATS. And, 62% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 29.7 to 23.2 with Louisville winning on the moneyline, Kentucky winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on November 23, 2023 at 7:27AM ET.
img CFB

Kentucky at Louisville

November 25, 2023
img12:00 PM Eastern

Kentucky is on a 1-5 SU/ATS slide. In their last three games against Top 25 opponents, the Wildcats lost 33-27, 51-13, and 49-21. Kentucky is 16-27 ATS in November games, plus 10-20 ATS off a road loss. Louisville has lost just one game this season and is 2-0 against Top 20 teams, winning 33-20 over No. 10 Notre Dame and 23-0 over No. 20 Duke. They're on a 10-2 spread run at home and have a defense that is 23rd in the country in points allowed (20.2 per game). Louisville is 27-13 ATS against winning teams and coach Jeff Brohm is 24-7 ATS versus opponents who average 4.75+ yards rushing per carry. Play Louisville.

Final Score

1
2
3
4
F
Kentucky Wildcats img
0
7
14
17
38
Louisville Cardinals
7
3
14
7
31
November 26, 2022 3:00pm ET
@
Louisville Cardinals
Louisville Cardinals
#159
Kentucky Wildcats
Kentucky Wildcats
#160

Lines & Odds

+3.5 (-110)
ATS
-3.5 (-110)
+146
Moneyline
-169
OVER 42.5 (-110)
Total
UNDER 42.5 (-110)

Public Consensus

Who was the public on? 60% of the public bets were on Kentucky Wildcats on the -3.5 ATS. And, 52% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Kentucky would win by a score of 23.7 to 21.5 with Kentucky winning on the moneyline, Louisville winning on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on November 24, 2022 at 1:41PM ET.
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Louisville at Kentucky

November 26, 2022
img3:00 PM Eastern

Louisville has won five of its past six games with the only loss being against Clemson and the Cardinals come off a 25-10 victory over N.C. State on Saturday. Louisville used a balanced offense against the Wolfpack as Brock Domann threw for 153 yards and Jawhar Jordan ran for 105 yards on 16 carries and N.C. State was held to 77 yards rushing. Louisville is #37 in the country in total yards allowed and #20 in scoring defense allowing 19.6 points per game. Kentucky allows 19.6 points, but the Wildcats have lost five of their past seven games, including a 24-21 loss as a 17-point favorite against Vanderbilt and then losing 16-6 to top-ranked Georgia last week. Kentucky is averaging only 16.3 points its last seven games. Will Levis completed 20 of 31 for 206 yards against the Bulldogs, but with just one TD pass and an interception. This is a huge revenge game for Louisville, which was routed 52-21 in last year's meeting and the Cardinals have covered five of their last six games and they have gone UNDER four of their last five. Kentucky has stayed UNDER five straight following a loss and they are 11-1 UNDER their past 12 games overall. Take Louisville (Max Play), and play this game to stay UNDER.

Final Score

1
2
3
4
F
Louisville Cardinals
0
7
0
6
13
Kentucky Wildcats img
7
6
10
3
26
November 27, 2021 7:30pm ET
@
Kentucky Wildcats
Kentucky Wildcats
#165
Louisville Cardinals
Louisville Cardinals
#166

Lines & Odds

+3 (-115)
ATS
-3 (-105)
+123
Moneyline
-143
OVER 57.5 (-110)
Total
UNDER 57.5 (-110)

Public Consensus

Who was the public on? 61% of the public bets were on Kentucky Wildcats on the +3 ATS. And, 62% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 29.8 to 28.0 with Louisville winning on the moneyline, Kentucky winning on the spread and the game going OVER the total.

Pro Picks

These Pro Picks were released to clients on November 24, 2022 at 1:41PM ET.
img CFB

Kentucky at Louisville

November 27, 2021
img7:30 PM Eastern

Both teams come off blowout wins against terrible defenses, but playing each other will be a different story as Louisville allows 24.7 points per game compared to 22.2 for Kentucky. The Wildcats' wins this season have come against bad to mediocre teams, including 56-16 last week against New Mexico State, which is 1-10. Louisville destroyed Duke 62-22 while racking up 384 yards rushing on only 37 carries and QB Malik Cunningham accounted for most of the offense with 303 yards passing and 224 more on the ground in what is one of the best offensive games in history. Cunningham completed 18 of 25 with five touchdowns and no interceptions. Obviously, he's not expected to come near to duplicating those numbers against the Wildcats, but he is capable of a dominant performance. The Cardinals are 8-3 ATS their past 11 games as favorites, 5-0 UNDER as home favorites. Kentucky is 11-3 UNDER as a road underdog and 1-4-1 ATS its last six November games. Play Louisville ATS as my first pick on this game, and also take the UNDER as a Max Play

Final Score

1
2
3
4
F
Kentucky Wildcats img
14
10
14
14
52
Louisville Cardinals
7
0
0
14
21

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