James Madison Dukes vs Louisville Cardinals Point Spread Picks

Dukes vs. Cardinals Spread Picks

Get this week's Dukes vs. Cardinals point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Dukes vs. Cardinals.

Public Consensus

Who was the public on? 54% of the public bets were on Louisville Cardinals on the -15 ATS. And, 66% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 35.5 to 22.1 with Louisville winning on the moneyline, James Madison winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on September 05, 2025 at 11:09AM ET.

PARLAY

Louisville (CFB-314) MONEYLINE + Maryland (CFB-316) MONEYLINE

September 5, 2025

7:00 PM Eastern

Combine the Cardinals (-620) and the Terrapins (-730) into a 2-team parlay at -312 odds.

Final Score

1

2

3

4

F

James Madison Dukes

7

0

7

0

14

Louisville Cardinals

0

6

8

14

28

Public Consensus

Who was the public on? 58% of the public bets were on Louisville Cardinals on the -6.5 ATS. And, 63% of the bets were on the game to go OVER the total.

Computer Predictions

My computer prediction for this game was that Louisville would win by a score of 29.7 to 24.0 with Louisville winning on the moneyline, James Madison winning on the spread and the game going OVER the total.

Pro Picks

This Pro Pick was released to clients on November 02, 2023 at 10:12AM ET.

CFB

James Madison at Louisville

November 5, 2022

7:30 PM Eastern

James Madison is in their first season in the FBS. They were an annual power in the FCS. They opened the season at 5-0, but have stumbled in their last two games. They allowed 578 passing yards to Georgia Southern and generated just 247 yards vs Marshall. Worse than that they turned the ball over nine times in the two games. This team will ultimately be good at the FBS level, but depth is a problem now and it is starting to show. Louisville has played a significantly stronger schedule, with better numbers. The Cardinals are balanced, and the better team on both sides of the ball. I don't think this one is as close as the oddsmakers suggest. Mke the play on Louisville.

Final Score

1

2

3

4

F

James Madison Dukes

3

7

0

0

10

Louisville Cardinals

7

3

10

14

34