The Illinois defense is loaded with talent. Linebacker Gabe Jacas is a pass-rushing force, while the secondary is outstanding, anchored by two-time All-Big Ten Star Xavier Scott. The offense lost a lot of production at wideout, but has deep running back depth, rushing for 209 yards in the opener. Illinois is on a 23-13-1 run UNDER the total. Duke had an attacking defense under first-year coach Manny Diaz last year and looks very good again with a strong returning front line. The secondary has shut down CB Chandler Rivers and ball-hawking safety Terry Moore. The offense can run with four returning starters on the O-line, plus RBs Jaquez Moore and Anderson Castle. Take Illinois/Duke UNDER the total.
Upcoming Matchup & Picks
September 12, 2026 3:30pm ET
@
Duke Blue Devils
#349
Illinois Fighting Illini
#350
Lines & Odds
ATS
Moneyline
Total
Blue Devils vs. Fighting Illini Spread Picks
Get this week's Blue Devils vs. Fighting Illini point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Blue Devils vs. Fighting Illini.
Computer Predictions
My computer prediction for this game is that Duke will win by a score of 0.0 to 0.0.
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Previous Matchups & Picks
September 6, 2025 12:00pm ET
@
Illinois Fighting Illini
#335
Duke Blue Devils
#336
Lines & Odds
-2.5 (-110)
ATS
+2.5 (-110)
-135
Moneyline
+113
OVER 49 (-110)
Total
UNDER 49 (-110)
Public Consensus
Who was the public on? 67% of the public bets were on Illinois Fighting Illini on the -2.5 ATS. And, 59% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that Illinois would win by a score of 27.3 to 22.5 with Illinois winning on the moneyline and on the spread and the game going OVER the total.
Pro Picks
This Pro Pick was released to clients on September 04, 2025 at 2:49PM ET.
CFB
Illinois at Duke
September 6, 2025
12:00 PM Eastern
Final Score
1
2
3
4
F
Illinois Fighting Illini 
7
7
14
17
45
Duke Blue Devils
3
10
6
0
19
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