Few could have imagined before the season that Penn State and Clemson would end up playing in the Pinstripe Bowl. Both had extremely disappointing seasons. Given all of Clemson's opt-outs, Penn State is the superior team. Clemson's defense will have plenty of high draft picks, but these players won't be on the field. The list includes first-team All-ACC members defensive tackle Peter Woods and cornerback Avieon Terrell, along with standout pass rusher TJ Parker, safety Khalil Barnes, and linebacker Wade Woodaz, who finished second on the team with 70 tackles. Antonio Williams, the Tigers' best wide receiver, also won't play. Ethan Grunkemeyer took over for injured QB Drew Allar and finished with the highest completion percentage (69.4%) in Penn State history. Penn State had competitive losses to Oregon, Iowa, and Indiana while competing in the tougher Big Ten Conference. The game is in New York, where the forecast is for a cold day with a chance of rain and snow. The weather favors Penn State against the Southern team. Take Penn State on the moneyline.
Previous Matchups & Picks
December 27, 2025 12:00pm ET
vs.
Penn State Nittany Lions
#227
Clemson Tigers
#228
Lines & Odds
+2.5 (-110)
ATS
-2.5 (-110)
+115
Moneyline
-136
OVER 47.5 (-115)
Total
UNDER 47.5 (-105)
Nittany Lions vs. Tigers Spread Picks
Get this week's Nittany Lions vs. Tigers point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Nittany Lions vs. Tigers.
Public Consensus
Who was the public on? 50% of the public bets were on Clemson Tigers on the -2.5 ATS. And, 57% of the bets were on the game to go UNDER the total.
Computer Predictions
My computer prediction for this game was that Penn State would win by a score of 24.7 to 24.4, Penn State winning on the spread and the game going OVER the total.
Pro Picks
This Pro Pick was released to clients on December 26, 2025 at 8:16AM ET.
Penn State vs. Clemson
December 27, 2025
Final Score
1
2
3
4
F
Penn State Nittany Lions
3
3
0
16
22
Clemson Tigers
0
3
0
7
10
CFB Pro Pick Results
Here’s how my Pro Picks are performing.
CFBCFB
All Picks last 13.7 years
Wins
Losses
Units
2,344
2,139
+93.02
CFBCFB
Max Plays last 9.1 years
Wins
Losses
Units
284
228
+73.57
CFBCFB
All Playoff Picks last 17.1 years
Wins
Losses
Units
322
295
+52.15
CFBCFB
Free Picks last 14.0 years
Wins
Losses
Units
152
113
+38.27
CFBCFB
Free Picks this season last 7 days
Wins
Losses
Units
1
0
+1.39
CFBCFB
Between teams last 1 day
Wins
Losses
Units
1
0
+1.46
Get free CFB Picks
I pour over the data, injuries, news, and odds every morning. You get the best bets delivered to your inbox.
Get a top-rated pick every day.