Boston College routed Fordham to open the season, but it hasn't won since. They've used three quarterbacks and get no help from an anemic ground game that averages 3.3 yards per rush. The defense has been particularly weak, ranking 114th in total yards allowed (435.5 per game) and 138th in points allowed (37.8 per game). The Eagles come off a 38-23 loss at home to UConn, surrendering 455 yards. No. 19 Louisville is flying high after a 24-21 win at No. 2 Miami as a double-digit underdog. Senior QB Miller Moss (9 TDs, 4 INTs) leads an offense that is averaging 30.6 points, while the defense is 13th in the nation in yards allowed. Play Louisville.
Previous Matchups & Picks
October 25, 2025 7:30pm ET
@
Boston College Eagles
#133
Louisville Cardinals
#134
Lines & Odds
+25.5 (-110)
ATS
-25.5 (-110)
+1311
Moneyline
-3546
OVER 54.5 (-110)
Total
UNDER 54.5 (-110)
Eagles vs. Cardinals Spread Picks
Get this week's Eagles vs. Cardinals point spread picks, including expert ATS picks, computer model projections, betting consensus trends, matchup analysis, key wagering angles, and the latest odds insights for the upcoming game between Eagles vs. Cardinals.
Public Consensus
Who was the public on? 53% of the public bets were on Louisville Cardinals on the -25.5 ATS. And, 67% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 40.5 to 15.0 with Louisville winning on the moneyline and on the spread and the game going OVER the total.
Pro Picks
This Pro Pick was released to clients on October 23, 2025 at 9:49AM ET.
CFB
Boston College at Louisville
October 25, 2025
7:30 PM Eastern
Final Score
1
2
3
4
F
Boston College Eagles
3
7
7
7
24
Louisville Cardinals 
7
14
7
10
38
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October 25, 2024 7:30pm ET
@
Louisville Cardinals
#115
Boston College Eagles
#116
Lines & Odds
-7 (-105)
ATS
+7 (-115)
-258
Moneyline
+218
OVER 54 (-110)
Total
UNDER 54 (-110)
Public Consensus
Who was the public on? 62% of the public bets were on Boston College Eagles on the +7 ATS. And, 60% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 31.4 to 22.3 with Louisville winning on the moneyline and on the spread and the game going UNDER the total.
Final Score
1
2
3
4
F
Louisville Cardinals
0
7
10
14
31
Boston College Eagles
7
13
7
0
27
September 23, 2023 3:30pm ET
@
Boston College Eagles
#331
Louisville Cardinals
#332
Lines & Odds
+14 (-110)
ATS
-14 (-110)
+419
Moneyline
-575
OVER 53.5 (-110)
Total
UNDER 53.5 (-110)
Public Consensus
Who was the public on? 55% of the public bets were on Louisville Cardinals on the -14 ATS. And, 57% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 36.5 to 18.8 with Louisville winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
Boston College Eagles
0
14
7
7
28
Louisville Cardinals
14
28
14
0
56
October 1, 2022 12:00pm ET
@
Louisville Cardinals
#119
Boston College Eagles
#120
Lines & Odds
-13.5 (-110)
ATS
+13.5 (-110)
-548
Moneyline
+399
OVER 48 (-110)
Total
UNDER 48 (-110)
Public Consensus
Who was the public on? 53% of the public bets were on Boston College Eagles on the +13.5 ATS. And, 51% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 31.7 to 20.9 with Louisville winning on the moneyline, Boston College winning on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
Louisville Cardinals
7
16
10
0
33
Boston College Eagles
7
14
7
6
34
October 23, 2021 4:00pm ET
@
Boston College Eagles
#339
Louisville Cardinals
#340
Lines & Odds
+4 (-110)
ATS
-4 (-110)
+164
Moneyline
-188
OVER 57.5 (-110)
Total
UNDER 57.5 (-110)
Public Consensus
Who was the public on? 54% of the public bets were on Boston College Eagles on the +4 ATS. And, 56% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 31.4 to 28.2 with Louisville winning on the moneyline, Boston College winning on the spread and the game going OVER the total.
Final Score
1
2
3
4
F
Boston College Eagles
7
0
0
7
14
Louisville Cardinals
7
14
0
7
28
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