Oregon vs. USC

Coach Andy Enfield has spent several years building the USC program to prominence, and this is perhaps his most talented squad as the Trojans are 24-7 straight up and 18-13 ATS after easily winning their first two games of the NCAA Tournament. The Trojans have won five of their past six games, and they come from an obviously underrated Pac-12 Conference that is doing wonders in the tourney so far. Isaiah Mobley hit four 3-pointers and scored 17 points, and his All-American brother, Evan, added 10 points and 13 rebounds as the Trojans annihilated Kansas, 85-51, on Monday. The Jayhawks were held to 29% shooting and 6 of 25 from 3-point range. USC won the only meeting this season, 72-58, on Feb. 22 as a 3.5-point favorite. The Ducks were held to a .404 field goal percentage. The Trojans are 6-0 ATS their past six NCAA Tournament games and 18-8 ATS their last 26 neutral-site games. Take USC.