This pick was released to clients on November 21, 2025 at 11:23AM ET.
img CBB

Louisville at Cincinnati

November 21, 2025
img6:30 PM Eastern

This will be a big game as the 4-0 and #6-ranked Louisville heads to Cincinnati, which is also 4-0 on the season. Louisville has averaged 103 PPG. This will be a much different game than any of their previous four opponents. Cincinnati is allowing just 61 PPG, is playing at home, and opponents are shooting just 36% against them. The Bearcats have done a great job of running opponents off the line, allowing just 27% from deep. Louisville is no slouch on defense, as its four opponents have shot 39% on average. This game isn't going to make it into the 160s. I'm playing the UNDER.

1 unit on Game Total UNDER 164.5 -110 (risk 1 to return 1.91)
Result:
WIN
Final
1H
2H
F
Louisville Cardinals img
32
46
74
Cincinnati Bearcats
32
32
64
consensus consensus
odds odds
 
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