It's the second straight road game for Notre Dame, after losing at Syracuse, scoring 72 points while shooting 6-of-22 from long range (27%). The offense ranks 16th in the 18-team ACC in scoring (74 per game), 11th in shooting, and 12th from the free-throw line (.699). Louisville comes off a home win over SMU, allowing 74 points while forcing 16 turnovers. The defense ranks sixth in points allowed (70.5 per game) and fifth in shooting percentage (.404). Louisville is on an 11-6 run UNDER the total. Take Notre Dame/Louisville UNDER the total.
Previous Matchups & Picks
February 4, 2026 7:00pm ET
@
Notre Dame Fighting Irish
#681
Louisville Cardinals
#682
Lines & Odds
+18.5 (-110)
ATS
-18.5 (-110)
+1108
Moneyline
-2371
OVER 155.5 (-110)
Total
UNDER 155.5 (-110)
Fighting Irish vs. Cardinals Spread Picks
Get Fighting Irish vs. Cardinals point spread picks, expert spread analysis, computer model picks, betting consensus data, matchup breakdowns, key betting angles, and the latest odds insights for today's Fighting Irish vs. Cardinals game.
Public Consensus
Who was the public on? 62% of the public bets were on Notre Dame Fighting Irish on the +18.5 ATS. And, 56% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 85.5 to 68.5 with Louisville winning on the moneyline, Notre Dame winning on the spread and the game going UNDER the total.
Pro Picks
This Pro Pick was released to clients on February 04, 2026 at 12:22PM ET.
CBB
Notre Dame at Louisville
February 4, 2026
7:00 PM Eastern
Final Score
1H
2H
F
Notre Dame Fighting Irish
32
33
65
Louisville Cardinals 
38
38
76
CBB Pro Pick Results
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Free Picks last 13.3 years
Wins
Losses
Units
386
346
+5.09
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All Picks last 6.1 years
Wins
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Units
9
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Between teams last 1 day
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Units
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February 16, 2025 8:00pm ET
@
Louisville Cardinals
#867
Notre Dame Fighting Irish
#868
Lines & Odds
-7.5 (-110)
ATS
+7.5 (-110)
-353
Moneyline
+276
OVER 148 (-110)
Total
UNDER 148 (-110)
Public Consensus
Who was the public on? 61% of the public bets were on Louisville Cardinals on the -7.5 ATS. And, 58% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 76.9 to 70.8 with Louisville winning on the moneyline, Notre Dame winning on the spread and the game going UNDER the total.
Final Score
1H
2H
F
Louisville Cardinals
35
40
75
Notre Dame Fighting Irish
28
32
60
February 21, 2024 7:00pm ET
@
Notre Dame Fighting Irish
#687
Louisville Cardinals
#688
Lines & Odds
+3 (-110)
ATS
-3 (-110)
+137
Moneyline
-160
OVER 136.5 (-110)
Total
UNDER 136.5 (-110)
Public Consensus
Who was the public on? 69% of the public bets were on Louisville Cardinals on the -3 ATS. And, 55% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Louisville would win by a score of 68.9 to 66.8 with Louisville winning on the moneyline, Notre Dame winning on the spread and the game going UNDER the total.
Final Score
1H
2H
F
Notre Dame Fighting Irish
31
41
72
Louisville Cardinals
25
25
50
January 28, 2023 12:00pm ET
@
Louisville Cardinals
#605
Notre Dame Fighting Irish
#606
Lines & Odds
+9 (-110)
ATS
-9 (-110)
+353
Moneyline
-468
OVER 137.5 (-110)
Total
UNDER 137.5 (-110)
Public Consensus
Who was the public on? And, 61% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 75.9 to 64.1 with Notre Dame winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1H
2H
F
Louisville Cardinals
24
38
62
Notre Dame Fighting Irish
46
30
76
February 9, 2022 7:00pm ET
@
Louisville Cardinals
#687
Notre Dame Fighting Irish
#688
Lines & Odds
+6.5 (-110)
ATS
-6.5 (-110)
+253
Moneyline
-301
OVER 133.5 (-110)
Total
UNDER 133.5 (-110)
Public Consensus
Who was the public on? 60% of the public bets were on Notre Dame Fighting Irish on the -6.5 ATS. And, 54% of the bets were on the game to go OVER the total.
Computer Predictions
My computer prediction for this game was that Notre Dame would win by a score of 72.1 to 65.3 with Notre Dame winning on the moneyline and on the spread and the game going OVER the total.
Final Score
1H
2H
F
Louisville Cardinals
23
34
57
Notre Dame Fighting Irish
35
28
63
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