Iowa State Cyclones vs Mississippi State Bulldogs Point Spread Picks

This is a neutral-court game in Sioux Falls, South Dakota. Iowa State is a national title contender with three top returning starters in Tamin Lipsey, Milan Momcilovic, and Joshua Jefferson. The Cyclones easily disposed of their first two opponents, Fairleigh Dickinson and Grambling State, by an average of 39 points. They shot 55 percent and hit 12 3s in their 102-62 rout of Grambling State, and it went OVER by 19 points. Mississippi State features guard Josh Hubbard, who averaged 18.9 points in 2024-25 while shooting 34.5 percent from 3-point range. The Bulldogs defeated North Alabama in their season opener with Hubbard scoring 27 points. They have gone OVER seven of their past nine games, and the Bulldogs are 5-0 OVER as underdogs dating to last season. The Cyclones are 7-0-1 ATS after scoring more than 90 points in their previous game, 4-0 ATS after scoring at least 100. Iowa State is 5-1 ATS after winning by at least 20 points. Mississippi State finished last season 1-5 ATS against teams with winning records. Take Iowa State and the OVER.