Tennessee at San Francisco

San Francisco is giddy with the prospect of Jimmy Garoppolo becoming a franchise quarterback, but the 49ers are favored this week and they are 0-8 ATS in that situation dating to previous seasons. Tennessee is battling for a playoff spot while the Niners still are only 3-10 on the season and the three wins have been against the New York Giants, Chicago and Houston, none of which is a playoff contender. Marcus Mariota looks to bounce back from a 12-7 loss to Arizona in which he was intercepted twice and finished 16-of-31 for 159 yards.  Mariota has a left knee sprain, but is expected to start on Sunday. Tennessee has still won six of its last eight games and the Titans are 5-2-1 OVER their last eight games after scoring fewer than 15 points in their previous game. Also, the Titans are 11-5-1 OVER their last 17 games after a loss dating to the last two seasons. The 49ers are #25 defensively, allowing 351.8 yards per game and they give up an average of 24.2 points, which is only #23 in the league. Tennessee is 7-3 ATS its last 10 games after a loss.  Play the Titans and the OVER.