San Francisco at Los Angeles

Los Angeles comes off a huge win at Tampa Bay on Monday night and now goes home and has to play on a short week against the 49ers, who are desperate for a victory to stay in playoff contention. San Francisco had a much-needed bye week as it has been riddled with injuries all season, and the Niners hope the rest will do them good in a must-win situation. Also, they might get running backs Raheem Mostert and Jeff Wilson, Jr. back as both had their practice windows opened. Even with all the injuries, San Francisco still is #7 in the league in total yards allowed per game and the 49ers are #5 in passing defense. The 49ers won the first meeting, 24-16, and they have covered five of the last seven meetings at Los Angeles and seven of the last 10 meetings overall. Take the points with the 49ers.