Indianapolis at Los Angeles

It was a dismal August for Indianapolis, culminating in star QB Andrew Luck's retirement. Now they open the season on the road on the West Coast. QB Jacoby Brissett has to step in and the Colts are 1-10 ATS in Week 1, losing 34-23 at home in last season's opener. They face a Los Angeles Chargers team off a strong campaign along with a terrific offseason, adding veteran linebacker Thomas Davis and nabbing safety Nasir Adderley in the draft. They stocked up on an already strong D-line by adding defensive tackle Cortez Broughton, LB Emeke Egbule, and edge defender Chris Peace. This defense was top 10 in 2018 in points allowed (20.6 points per game), total 'D', run and pass defense. QB Philip Rivers is off a season where he threw 32 TDs, 12 picks and returns plenty of talented targets. The Chargers are 29-5 ATS against the AFC South Division, including 7-2 ATS against the Colts. Play the LA Chargers.