Arizona at San Francisco

San Francisco has a short week to recover from Monday's thriller when they lost in overtime, and they're laying double digits in this one. Arizona is only 3-6-1, but the Cardinals still have been a moneymaker this season with a 7-3 ATS record. The Niners won the first meeting, 28-25, as a 10.5-point favorite, and now they get the Cardinals again in a possible letdown situation after losing their first game of the season to the Seahawks. Kyler Murray's rookie record streak of consecutive passes without an interception ended at 211 in the Cardinals' loss to Tampa Bay. Arizona was victimized by a costly pass interference call in the end zone in the final two minutes. The 49ers are 1-5 ATS their last six games against teams with losing records, and the underdog has covered five of the last six meetings. The Niners are 5-13 ATS their last 18 versus the NFC, including 2-7 ATS versus NFC West teams. The UNDER is 16-7 in San Francisco's last 23 November games, and the Niners are 6-2 UNDER following a loss dating to last season. Take the Cardinals for a Max Play and the UNDER.